1 min read
Two hundred twenty-two nanometres ultraviolet (UV) light produced by a krypton–chlorine excimer lamp is harmful to bacterial cells but not skin. However, the effects of 222-nm UV light exposure to the eye are not fully known. We evaluated acute corneal damage induced by 222- and 254-nm UV light in albino rats. Under deep anaesthesia, 6-week-old Sprague–Dawley albino rats were exposed to UV light. The exposure levels of corneal radiation were 30, 150, and 600 mJ/cm2. Epithelial defects were detected by staining with fluorescein. Superficial punctate keratitis developed in corneas exposed to more than 150mJ/cm2 of UV light, and erosion was observed in corneas exposed to 600mJ/cm2 of UV light. Haematoxylin and eosin staining also showed corneal epithelial defects in eyes exposed to 254-nm UV light. However, no damage developed in corneas exposed to 222-nm UV light. Cyclobutane pyrimidine dimer-positive cells were observed only in normal corneas and those exposed to 254-nm UV light. Although some epithelial cells were stained weakly in normal corneas, squamous epithelial cells were stained moderately, and the epithelial layer that was detached from the cornea exposed to 600mJ/cm2 of light was stained intensely in corneas exposed to 254-nm UV light. In the current study, no corneal damage was induced by 222-nm UV light, which suggested that 222-nm UV light may not harm rat eyes within the energy range and may be useful for sterilising or preventing infection in the future.
Latest articles from UV Medico
Repetitive irradiation with 222nm UVC noncarcinogenic, safe for sterilizing human skin
UV Medico : Mar 4, 2024 3:09:25 PM
1 min read
Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses
UV Medico : Mar 5, 2024 10:02:51 AM
Harmless Effects of Sterilizing 222-nm far-UV Radiation on Mouse Skin and Eye Tissues
UV Medico : Mar 5, 2024 9:02:55 AM
1 min read
Long-term effects of 222 nm ultraviolet radiation C sterilizing lamps on mice susceptible to ultraviolet radiation
UV Medico : Mar 5, 2024 8:59:06 AM
1 min read
Evaluation of acute reactions on mouse skin irradiated with 222 and 235 nm UV-C
UV Medico : Mar 4, 2024 3:00:25 PM